What is Factor V Leiden?

Factor V Leiden (FVL for short) is a hereditary genetic disorder that causes the blood to clot more than it should. While FVL in itself is harmless, it significantly increases the chances of life threatening complications such as deep vein thrombosis (DVT), strokes (CVA), heart attacks, and pulmonary embolisms (PE). In women it also increases the chances of having miscarriages.

Factor V Leiden affects 4 to 5 percent of Caucasians but only 1 percent of blacks. And even though it affects such a large population, many people live their entire lives never knowing they have it, or they will know yet it will never have any negative impact.

Since FVL is a hereditary disorder, people with it are considered to be heterozygous (one good gene and one bad) or homozygous (a bad gene from both parents). Homozygous people are much more likely to have complications due to FVL. But even for heterozygous individuals, chances are significantly increased when other risk factors for clotting are applied, such as smoking, obesity, surgery, birth control pills, air travel, etc.

My hematologist explains it like this- People with FVL fall onto a scale from 1 to 100. A person without FVL would be a 1 and have minimal risk of clotting Heterozygous people rank a 25. They are at minimal risk of clotting but should take precautions if they have an invasive surgery or other risk factors. Being homozygous increases a person's rank to between 50 and 75. These individuals have a high risk of clotting and should be closely monitored by a doctor when other risk factors are present.

My doctor labeled me at a 125..... way off the chart. I unfortunately have reoccurring DVTs and have had one, possibly more, CVAs since I was 32. My first DVT was when I was 18 years old.

Welcome to the Factor V Leiden Info Blog

Welcome to the Factor V Leiden Information Blog. This is a place where you will find information and articles relating to Factor V Leiden and other health issues. I hope you find this blog informative and helpful in teaching you or your family about FVL.

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